Liver cancer survival time tripled by virus

The virus used in the vaccine that helped eradicate smallpox is now working its magic on liver cancer. A genetically engineered version of the vaccinia virus has trebled the average survival time of people with a severe form of liver cancer, with only mild, flu-like side effects.

Thirty people with hepatocellular carcinoma received three doses of the modified virus – code-named JX-594 – directly into their liver tumour over one month. Half the volunteers received a low dose of the virus, the other half a high dose. Members of the low and high-dose groups subsequently survived for, on average, 6.7 and 14.1 months respectively. By contrast, trials several years ago showed that sorafenib, the best existing medication for this cancer, prolonged life by only three months.

Two of the patients on the highest viral dose were still alive more than two years after the treatment. "It's a very substantial survival benefit," says Laurent Fischer, president of Jennerex, the company in San Francisco developing the treatment under the trade name Pexa-Vec.

Besides shrinking the primary tumour, the virus was able to spread to and shrink any secondary tumours outside the liver. "Some tumours disappeared completely, and most showed partial destruction on MRI scans," says David Kirn, head of the study at Jennerex. Moreover, the destruction was equally dramatic in the primary and secondary tumours.

"This clinical trial is an exciting step forward to help find a new way of treating cancers," says Alan Melcher of the University of Leeds, UK, who was not involved in the study. "It helps demonstrate the cancer-fighting potential of viruses, which have relatively few side effects compared with traditional chemo or radiotherapy," he says. "If it proves effective in larger trials, it could be available to patients within five years."

The fact that the virus appears able to spread to secondary tumours suggests that simply injecting the virus into the bloodstream may be effective. A trial to compare this treatment with injecting the virus directly into a tumour is under way.

Targeted at cancer

The virus has had a gene coding for an enzyme called thymidine kinase snipped out. The enzyme enables the virus to recognise and infect dividing cells. By removing the gene, the virus's developers have reduced the likelihood of healthy dividing cells being infected.

Instead, the virus exclusively attacks cancerous tissue, by targeting two genes that have increased activity in tumour cells. One genes is associated with an epidermal growth factor receptor, which stimulates the cancer to grow. The other is associated with a vascular endothelial growth factor, which enables the cancer to recruit its own blood supply. The virus reduces the activity of both genes, causing the infected cancer cell to wither and die.

What's more, the virus carries extra genes to prod the body's own immune system into action against the cancer. One produces granulocyte colony stimulating factor, a protein that encourages production of extra white blood cells at sites of infection. The other produces a protein not naturally found in humans, called Lac-Z, that earmarks infected cells for destruction.

Fischer says that to date, more than 200 people have received the virus, which has also shown promise against other types of cancer, including those of the kidney and skin. But he warns that not everyone sees a benefit. "We know why patients respond, but not why they don't," he says.

Journal reference: Nature Medicine, DOI: 10.1038/nm.3089

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Adele wins best pop solo performance Grammy

LOS ANGELES: British songstress Adele won the Grammy for best pop solo performance, the first award handed out during the main event on the music industry's biggest night of the year.

The 24-year-old singer, who swept the board with six Grammys at last year's awards show, took the prize for a live rendition of her hit "Set Fire to the Rain."

"My good luck charm, J-Lo," she said as she accepted the award from Jennifer Lopez and Pitbull. "This is amazing. I wanted to come and be part of the night. I loved it last year, obviously," she added.

Last year she won best song, best record, best album for her breakthrough "21," best short video, best pop album and best pop artist, winning all six categories in which she was nominated.

Indie pop band fun. won best song for "We Are Young," one of six categories in which they were nominated at music's biggest awards show.

The New York group are also shortlisted for the key categories of best record, best album and best new artist at the 55th Grammys Awards.

- AFP/ir

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Did Google Earth error send murderer to wrong address?

Dennis and Merna Koula.

(Credit:
CBS News.com Screenshot by Chris Matyszczyk/CNET)

Sometimes, even after a murder conviction, some see reasonable doubt that the conviction was a righteous one.

Such is the case in the murder of Dennis and Merna Koula in La Cross, Wisc, a quiet community.

Their son Eric was found guilty and is currently serving two consecutive life-sentences for the murder of the wealthy couple.

It was Eric Koula who found the body. It was Eric Koula whose alibi didn't stand up. Eric Koula was broke.

Yet as CBS News' "48 Hours" reported, there are some inconsistencies that some can't quite put aside. They include John Christophersen, a special agent at the time with the Wisconsin Department of Justice.

It was said at the trial that Eric Koula treated his father as an ATM. There was a $50,000 check that he cashed right after his parents died.

It was a check from his father. Eric Koula had forged the signature -- something he claimed to have done many times.

But, as his attorney said at the trial: "What sort of an idiot would put a check in the bank the morning after they killed their parents, knowing that bank records are easy to get?"

To some eyes, the murder seemed like a professional hit. No valuables were taken. And there was no DNA evidence to implicate Eric Koula.

Moreover, there was another idea that investigators began to pursue at the time. A neighbor of the Koula's, Steve Burgess, freely admitted that he had received death threats. He was the president of a local bank.

More Technically Incorrect

And, as the CBS News investigation indicated (embedded, but there are some gaps in the audio), if you use Google Earth to locate Burgess' house, you get a surprise.

"48 Hours" correspondent Peter Van Sant said: "In fact, when you Google Earth Steve Burgess' address...the zoom into the house goes to the Koula's house, not to Steve Burgess' house."

Police say they discounted the threatening caller, as they located him and he had an alibi. But then could that individual have hired someone to do any allegedly required dirty work, a person who used Google Earth to go to the wrong house?

This story brings to mind the even more recent case of the alleged murder of Rodrigo Diaz. His friends claim that his GPS had led him to the wrong house.

The owner of that house allegedly became annoyed or threatened by the presence of Diaz and his friends. This resulted in Diaz being shot in what lawyers for the accused, Phillip Sailors, say was a case of self-defense.

The jury in the trial of Eric Koula believed there was enough evidence to convict him.

Others look at the evidence they see on Google Earth and still have their doubts.

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Year of the Snake: The Serpent Behind the Horoscope

On February 10, people all around the world will ring in the Lunar New Year with paper lanterns and firecrackers. At the heart of it all sits the snake, a slithery reptile feared for its sharp fangs and revered for its undeniable charm. (Watch videos of some of the world's deadliest snakes.)

Those born in the Year of the Snake are said to be intelligent and quick thinking, but they can also be dishonest and prone to show off. Though based on Chinese astrology, some of these traits are similar to characteristics of the actual serpent.

Snakes are known to be great at outsmarting their predators and prey. Their colorful, patterned skin makes them some of the best tricksters in the animal kingdom. And despite a bad rap as frightening creatures, snakes never fail to fascinate scientists, explorers, and zoo-goers. (See pictures of snakes.)

With more than 3,400 recognized species, snakes exhibit incredible diversity in everything from behavior and habitats to skin colors and patterns.

"As a vertebrate lacking in limbs, all snakes look largely like other snakes, yet they succeed in tremendous diversity in multiple directions," said Andrew Campbell, herpetology collections manager at the University of Kansas Biodiversity Institute.

To usher in the Year of the Snake, Campbell and herpetologist Dennis Ferraro at University of Nebraska-Lincoln weigh in on some of the snake's qualities that the Chinese zodiac predicts people born this year will have.

Horoscope: Snakes have an innately elegant personality but can also be ostentatious at times.

In Nature: Snakes come in all different colors, patterns, and textures, making them some of nature's most visually stunning creatures.

According to Campbell, the utility of their coloring falls into two main categories: to use as camouflage and to warn predators to stay away.

Among the most beautiful are the emerald tree boa (Corallus caninus)—whose vibrant green body is decorated with white stripes resembling lightning bolts—and the Brazilian rainbow boa (Epicrates cenchria), characterized by its iridescent skin and the large black rings down its back.

For some snakes, the diversity in color occurs within the same species, which is why Ferraro tells his student not to identify snakes by colors. For example, the polymorphic bush viper (Atheris squamigera), many of which are green, also come in shades of yellow, orange, red, and blue, as captured in photographer Guido Mocafico's "Serpent Still Life" photo series.

Horoscope: The snake is known to be the master seducer of the Chinese zodiac.

In Nature: Female garter snakes (Thamnophis) have all the luck with the gentlemen.

When a female garter snake is ready to mate, she announces it by producing chemicals called pheromones. Males, upon encountering the scent, immediately come crawling out and gather around the female in a large, wriggling "mating ball."

The competition intensifies when a male passing by the ball tries to fool the others by producing a scent that mimics that of the female, said Ferraro.

As soon as his rivals are led off in the wrong direction, the trickster slides right in. In areas with smaller populations of garter snakes, each ball consists of about 12 males and one female.

But in places like Manitoba, Canada, where garter snakes travel to certain areas to mate after coming out of hibernation, a mating ball can have thousands of males and only a hundred females.

Horoscope: Though snakes don't often tell lies, they will use deception when they feel it's necessary and they think they can get away with it.

In Nature: When it comes to using trickery to catch dinner, or to hide from predators, snakes are no amateurs.

Their sneaky techniques range from tricking fish to swim right into their mouths, to playing dead when threatened, to using their wormlike tails to lure in prey.

The most cunning of them all is the two-headed snake. To protect against a sneak attack from behind, the two-headed snake's tail looks just like its head. While the business end looks for food, the snake coils up its body and rests its tail on top to look like it is on guard.

The tail can even mimic the behavior of a retreating snake to trick predators into thinking they're going face-to-face with their opponent.

Horoscope: When snakes get down to work, they are organized and highly efficient, and they work quickly and quietly.

In Nature: While snakes are often perceived as lazy, Campbell said people are mistaken. "What we perceive as shy, lazy, or inactive is really efficiency," he said.

"On average, they are bigger than other lizards and can build a lot of body mass. They do that by being efficient in feeding and traveling." In other words, snakes don't move very much because they don't have to.

When it comes to food, snakes catch prey that are significantly larger than them so they can eat less frequently. This reduces the time they spend hunting and thus makes them less vulnerable to falling victim to a predator themselves.

For Campbell, the most impressive hunter is the eastern diamondback rattlesnake (Crotalus Adamanteus), which is able to hunt and kill its prey very quickly using venom, so it doesn't have to travel far. "Because they don't have to do that, they can become relatively large and heavy, being able to build up body mass and not having to spend that energy hunting."

Horoscope: Snakes are charming, with excellent communication skills.

In Nturea: For snakes, their visual and auditory senses don't mean much when it comes to communicating with each other.

Instead, they use their sense of smell and the chemicals produced by their musk glands. Unlike mammals, a snake picks up scent through the forks of its tongue.

When the snake retracts its tongue, it inserts the forks into grooves in an olfactory organ located at the roof of its mouth. Depending on which fork picks up a stronger scent, the snake knows in which direction to go when looking for prey or a mate.

It's when snakes are threatened that they use sight and sound, said Ferraro. Rattlesnakes, for example, shake their tails, making a loud rattling noise to ward off predators.

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$1M Reward for Capture of Fugitive Ex-Cop Dorner

A $1 million reward was offered today for information leading to the arrest of Christopher Dorner, as authorities in Big Bear, Calif., scaled back their search for the disgruntled ex-cop, who is suspected in three revenge killings.

"This is the largest local reward ever offered, to our knowledge," Los Angeles Police Chief Charlie Beck said at a news conference today. "This is an act of domestic terrorism. This is a man who has targeted those that we entrust to protect the public. His actions cannot go unanswered."

The money for the reward was pooled by businesses, government, local law enforcement leaders and individual donors, Beck said.

PHOTOS: Former LAPD Officer Suspected in Shootings

The reward comes on the fourth day of a manhunt for Dorner, who has left Southern California on edge after he allegedly went on a killing spree last week to avenge his firing from the police force. Dorner outlined his grievances in a 6,000 word so-called "manifesto" and said he will keep killing until the truth is known about his case.

Dorner's threats have prompted the LAPD to provide more than 50 law enforcement families with security and surveillance detail, Beck said.

Authorities are chasing leads, however they declined to say where in order to not impede the investigation.

Dorner's burned-out truck was found Thursday near Big Bear Lake, a popular skiing destination located 80 miles northeast of Los Angeles.

Irvine Police Department/AP Photo

Manhunt for Alleged Cop Killer Heads to California Mountains Watch Video

Christopher Dorner Search: Officials Search for Ex-officer in the Mountains Watch Video

Investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned, sources told ABC News.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

Full Coverage: Christopher Jordan Dorner

Officers have spent the past couple of days going door-to-door and searching vacant cabins. The manhunt was scaled back to 25 officers and one helicopter in the resort town today, according to the San Bernadino Sheriff's Office.

On Saturday, Beck announced he would reopen the investigation into Dorner's firing but said the decision was not made to "appease" the fugitive ex-cop.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," Beck said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint."

Dorner is suspected of killing Monica Quan and her fiancé Keith Lawrence last Sunday in their car in the parking lot of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

Quan's father, Randall Quan, was a retired captain with the LAPD and attorney who represented Dorner before a police review board that led to Dorner's dismissal from the force in 2008.

On Wednesday, after Dorner was identified as a suspect in the double murder, police believe he ambushed two Riverside police officers, killing one and wounding the other.

The next day, Randall Quan reported he received a taunting call from a man claiming to be Dorner who told him that he "should have done a better job of protecting his daughter," according to court documents documents.

Anyone with information leading to the arrest of Christopher Dorner is asked to call the LAPD task force at 213-486-6860.

ABC News' Dean Schabner, Jack Date, Pierre Thomas, Jason Ryan and Clayton Sandell contributed to this report.

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Sooty ships may be geoengineering by accident

GEOENGINEERING is being tested - albeit inadvertently - in the north Pacific. Soot from oil-burning ships is dumping about 1000 tonnes of soluble iron per year across 6 million square kilometres of ocean, new research has revealed.

Fertilising the world's oceans with iron has been controversially proposed as a way of sucking carbon dioxide out of the atmosphere to curb global warming. Some geoengineers claim releasing iron into the sea will stimulate plankton blooms, which absorb carbon, but ocean processes are complex and difficult to monitor in tests.

"Experiments suggest you change the population of algae, causing a shift from fish-dominated to jellyfish-dominated ecosystems," says Alex Baker of the University of East Anglia, UK. Such concerns led the UN Convention on Biological Diversity (CBD) to impose a moratorium on geoengineering experiments in 2010.

The annual ship deposition is much larger, if less concentrated, than the iron released in field tests carried out before the moratorium was in place. Yet because ship emissions are not intended to alter ocean chemistry, they do not violate the moratorium, says Jim Thomas of the ETC Group, a think tank that consults for the CBD. "If you intentionally drove oil-burning ships back and forth as a geoengineering experiment, that would contravene it."

The new study, by Akinori Ito of the Japan Agency for Marine-Earth Science and Technology, is the first to quantify how shipping deposits iron in parts of the ocean normally deficient in it. Earlier models had assumed that only 1 to 2 per cent of the iron contained in aerosols, including shipping emissions, is soluble in seawater, so the remaining 98 to 99 percent would sink to the bottom without affecting ocean life. But Ito found that up to 80 per cent of the iron in shipping soot is soluble (Global Biogeochemical Cycles, doi.org/kdj). As this soot rapidly falls to the sea surface, it is likely to be fertilising the oceans.

In the high-latitude north Pacific - a region that is naturally iron-poor and therefore likely to be most affected by human deposits - ship emissions now account for 70 per cent of soluble iron from human activity, with the burning of biomass and coal accounting for the rest. Shipping's share will rise as traffic continues to grow and regulations restrict coal and biomass emissions.

Can we learn anything from this unintentional experiment? Baker thinks not. "The process isn't scientifically useful," he says, because the uncontrolled nature of the iron makes it difficult to draw meaningful comparisons.

The depositions are unlikely to be harmful at current levels, he says, but "given the uncertainties, I just don't know how much these iron emissions would have to increase before there was demonstrable harm to an ecosystem, or benefit in terms of carbon uptake, for that matter".

This article appeared in print under the headline "Ships inadvertently fertilise the oceans"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Sony faces challenge with new PlayStation

SAN FRANCISCO: When Sony pulls back the curtain on the next-generation PlayStation videogame console, the world will see how much the Japanese consumer electronics titan has been paying attention.

Sony could double-down on hardware to power even more realistic graphics and rich game play than the impressive specifications of PlayStation 3 consoles nearing the end of a life cycle started in 2006.

Or, Sony may step towards a vision outlined by chief executive Kazuo Hirai by introducing an improved console as part of an ecosystem that weaves the company's film, music, games and electronics together with the trend towards getting home entertainment online.

"Sony needs a living room experience," Forrester Research analyst James McQuivey said while discussing expectations that a PlayStation 4 will be showcased at an event being hosted by Sony on February 20 in New York City.

"They need more software, not more hardware."

The PlayStation 3 launched as an engineering triumph complete with Blu-ray high-definition disk player capabilities only to see rival Microsoft score with Xbox 360 consoles for gaming as well as online films, music and more.

"Sony can't build a company on those few people who are hardcore gamers, so they have to figure out how to bridge to the all-purpose consumer who likes games, which is most of us," McQuivey said.

"If they emphasize how this is really a television set-top box with your favourite channels and Netflix, it will mean Sony has paid attention."

Sony has remained mum, but that hasn't stopped talk of hardware upgrades such as improved graphics and controllers with touchpads, and chatter of Sony announcing its own cable-style service to route film or music content to PlayStation consoles.

Sony needs to adapt to changing lifestyles while not alienating videogame lovers devoted to its hardware.

Low-cost or free games on smartphones or tablet computers are increasing the pressure on videogame companies to deliver experiences worth players' time and money.

New generation consoles are typically priced in the $400 to $500 range, and blockbuster game titles hit the market at $60 each.

"Sony is under a lot of pressure," said National Alliance Capital Markets analyst Mike Hickey. "Gamers are desperate for innovation and better games."

While Sony is tethered to "legacy" hardware, companies such as Apple and Google are driving innovation with tablets, smartphones, and ways to route Internet offerings to television sets, according to Hickey.

While ramping up content and services for PlayStation, Sony also needs to motivate people to upgrade from the current model.

"If Sony wants to win it, they need to show some killer games to get people to go out and spend a lot of money for the core game experience," Hickey said.

He blamed a dearth of compelling titles as a reason for disappointing sales of Nintendo's innovative Wii U consoles introduced late last year.

"The Wii U is a case study you can't ignore," Hickey said. "Sony at least has to nail it with the games; the core market can drive the mass market."

Industry tracker NPD Group reported that just shy of $9 billion was spent in the United States last year on purchasing or renting video or computer games.

Another $5.92 billion was spent on game downloads, subscriptions, and play on mobile games or at social networks, according to NPD.

French videogame star Ubisoft reported that sales surged 23 percent overall in the final quarter of last year with hit instalments of its "Assassin's Creed" and "Far Cry" franchises while online revenue leapt 143 percent.

"People are gaming more now than they ever have," McQuivey said. "More minutes on more devices over more types of games from consoles to mobile phones."

"Console gaming is going to face challenge because you can pull out your tablet and have some pretty amazing gaming experiences for $1.99 or free with ads," he added.

Forrester predicts that while US households will turn increasingly to accessing the Internet through videogame consoles and smart televisions, games on smartphones and tables will "negatively impact" the console market.

"Tablets are in every household and the computing power of tablets is going up every year," Hickey said. "Eventually, the tablet could very well become the console."

Analyst Michael Pachter of Wedbush Securities expected Sony to remain mum about pricing and specific release date while unveiling the PS4 later this month.

"The new console will clearly be more powerful," Pachter said. "How they will use that power is unclear."

- AFP/al

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LA Microsoft Store not mobbed, but Surface has a following

The Surface Pro

(Credit:
Brooke Crothers)

LOS ANGELES -- The launch of the Surface Pro at the Microsoft Store in LA's Century City was a relatively low-key affair compared with the debut of the Surface RT.

When I arrived just after 10 a.m. there was a small line (see photo). That said, both versions -- 64GB and 128GB -- of the
Surface Pro had sold out immediately.

Of course, no one would say how many units were set aside for first-day sales, and the lines didn't exactly snake around the Westfield Century City mall. So, it wasn't like a Depression-era run on a bank.

And back in October the lines were longer and the atmosphere a bit more frenzied when the Surface RT launched.

On Saturday, there was a small line outside the Century City Microsoft Store near Beverly Hills. The Surface Pro sold out immediately at the store.

(Credit:
Brooke Crothers)

But like the RT rollout, there was a fixation on and interest in the product not unlike what's found at an Apple event. I saw more than a few customers glued to the device for 30 minutes or even an hour.

In other words, Surface has a following. An analogy I would use is the Chevy Volt. Recently in LA, the Chevy Volt is gaining ground, driven by a small but growing (and fervent) customer base.

And Microsoft Store sales reps know what they're talking about. A patient, focused rep gave me a long, hands-on explanation of the
Windows 8 touch interface and demonstrated a new touch-enabled paint app, among other apps.

Finally, note that there are other enticing touch-screen Windows 8 devices at the store, including the 2.3-pound Acer Aspire S7 and the HP Spectre XT TouchSmart. And that's good for Windows 8 overall.

Looking at the line from inside the store.

(Credit:
Brooke Crothers)

The Surface Pro isn't the only cool Windows 8 device on sale at the Microsoft Store. The 11.6-inch Acer Aspire S7 touch-screen laptop is a tempting alternative to the Pro.

(Credit:
Brooke Crothers)

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Mars Rover Curiosity Completes First Full Drill

For the first time in history, humans have drilled a hole into rock on Mars and are collecting the powdered results for analysis, NASA announced Saturday.

After weeks of intensive planning, the Mars rover Curiosity undertook its first full drill on Friday, with NASA receiving images on Saturday showing that the procedure was a success.

Curiosity drilled a hole that is a modest 2.5 inches (6.35 centimeters) deep and .6 inches (1.52 centimeters) wide but that holds the promise of potentially great discoveries. (Watch video of the Mars rover Curiosity.)

"The most advanced planetary robot ever designed now is a fully operating analytical laboratory on Mars," John Grunsfeld, NASA associate administrator for the agency's Science Mission Directorate, said in a statement on Saturday.

"This is the biggest milestone accomplishment for the Curiosity team since the sky-crane landing last August."

Read: Asteroid to Make Closest Flyby in History

The site of the much-anticipated penetration is a flat section of Mars rock that shows signs of having been underwater in its past.

Called Yellowknife Bay, it's the kind of environment where organic materials—the building block of life—might have been deposited and preserved long ago, at a time when Mars was far wetter and warmer than it is today.

The contents of the drilling are now being transferred into the rover's internal collection system, where the samples will be sieved down to size and scoured to minimize the presence of contamination from Earth. (Watch video of Curiosity's "Seven Minutes of Terror.")

Then the sample will be distributed to the two instruments most capable of determining what the rocks contain.

The first is the Sample Analysis on Mars (SAM), which has two ovens that can heat the powdered rock to almost 2000°F (1093°C) and release the rock's elements and compounds in a gaseous form.

The gases will then be analyzed by instruments that can identify precisely what they are, and when they might have been deposited. Scientists are looking for carbon-based organics believed to be essential for any potentially past life on Mars.

Powder will also go to the Chemistry and Mineralogy (CheMin) instrument for a related analysis that looks especially at the presence of minerals—especially those that can only be formed in the presence of water.

Louise Jandura, chief engineer for Curiosity's sample system at NASA's Jet Propulsion Laboratory, said that designing and testing a drill that can grab hold of Martian rock and commence first a percussive shallow drilling and then dig a deeper hole was difficult.

The drill, which is at the end of a 7-foot arm, is capable of about 100 discrete maneuvers.

"To get to the point of making this hole in a rock on Mars, we made eight drills and bored more than 1,200 holes in 20 types of rock on Earth," Jandura said in a statement.

Results from the SAM and CheMin analyses are not expected for several days to weeks.

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LAPD Reopens Case of Suspected Cop-Killer's Firing

The Los Angeles Police Department announced today it will reopen the case of the firing of Christopher Dorner, but said the decision was not made to "appease" the fugitive former cop suspected of killing three people.

Dorner, a fired and disgruntled former Los Angeles police officer, said in the so-called "manifesto" he released that he was targeting LAPD officials and their families and will keep killing until the truth is known about his case.

"I have no doubt that the law enforcement community will bring to an end the reign of terror perpetrated on our region by Christopher Jordan Dorner and he will be held accountable for his evil actions," LAPD Chief Charlie Beck said in a statement released tonight.

He spoke of the "tremendous strides" the LAPD has made in regaining public trust, but added: "I am aware of the ghosts of the LAPD's past and one of my biggest concerns is that they will be resurrected by Dorner's allegations of racism within the Department."

To do that, he said, full re-investigation of the case that led to Dorner's firing in necessary.

"I feel we need to also publicly address Dorner's allegations regarding his termination of employment, and to do so I have directed our Professionals Standards Bureau and my Special Assistant for Constitutional Policing to completely review the Dorner complaint of 2007; To include a re-examination of all evidence and a re-interview of witnesses," he said. "We will also investigate any allegations made in his manifesto which were not included in his original complaint.

Irvine Police Department/AP Photo

Hundreds of Officers on Hunt for Alleged Cop Killer Watch Video

Christopher Dorner Manhunt: Ex-Cop Suspected in Killings Watch Video

"I do this not to appease a murderer. I do it to reassure the public that their police department is transparent and fair in all the things we do."

PHOTOS: Former LAPD Officer Suspected in Shootings

As police searched for Dorner today in the San Bernardino Mountains, sources told ABC News that investigators found two AR-15 assault rifles in the burned-out truck Dorner abandoned.

The truck had a broken axle, which may be the reason he decided to set fire to it, the police sources said.

A man identifying himself as Dorner taunted the father of Monica Quan four days after the former LAPD officer allegedly killed her and just 11 hours after he allegedly killed a police officer in Riverside, Calif., according to court documents obtained by ABC News

A man claiming to be Dorner called Randall Quan and told him that that he "should have done a better job of protecting his daughter," according to the documents.

In his 6,000-word "manifesto," Dorner named Randal Quan, a retired LAPD captain and attorney who represented him before a police review board that led to Dorner's dismissal from the force.

"I never had an opportunity to have a family of my own, I'm terminating yours," Dorner wrote, and directed Quan and other officials to "[l]ook your wives/husbands and surviving children directly in the face and tell them the truth as to why your children are dead."

Monica Quan and her fiancé Keith Lawrence were gunned down last Sunday in their car in the parking of their Irvine, Calif., condominium complex. Both were struck with multiple gunshot wounds.

The call, according to court records, was traced to Vancouver, Wash., but law enforcement officials do not believe Dorner was there at the time at the call.

Dorner is believed to have made the call early Thursday afternoon, less than half a day after he is suspected of killing a police officer and wounding two others early that morning, sparking an unprecedented man hunt involving more than a thousand police officers and federal agents spanning hundreds of miles.

FULL COVERAGE: Christopher Jordan Dorner

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